Bioequivalence and Bioavailability Forum

Winnonlin AUMC_TAU and others [Software]

posted by mittyri – Russia, 2017-01-18 19:00 (2647 d 09:32 ago) – Posting: # 16975
Views: 10,831
(edited by mittyri on 2017-01-18 20:20)

Hi Helmut and all,

❝ BTW, it is one of the mysteries of Phoenix/WinNonlin why the NCA’s MRT is correct though the AUMC isn’t. My pocket calculator gives 294.97/257.15=1.1471.

the formula for MRTINF (using Cpred version) is the following:

MRTINF_pred =

AUMC_TAU is a'cut-off' version like AUC_TAU.
BTW AUMC is calculated inside modeling like that:

AUMC = A1InfDose/(tvV*Ke*Ke) + (Tinf*A1InfDose/(2*tvV*Ke)

So the modeling version is AUMC extrapolated to infinity. If you remove Tau from the Dosing sheet in NCA object, you'll see AUMCINF_pred which is close enough to the AUMC value in PK model

Complete thread:

• WinNonlin: NCA of multiple dosing plasma PK profile bobmarlo 2017-01-15 17:22 
  • WinNonlin: steady state setup Helmut 2017-01-16 13:15
    • WinNonlin: steady state setup BE-proff 2017-01-17 07:54
      • Accumulation Helmut 2017-01-18 02:22
    • WinNonlin: steady state setup bobmarlo 2017-01-17 20:36
      • NCA agrees with PK-modeling Helmut 2017-01-18 01:41
        • NCA agrees with PK-modeling bobmarlo 2017-01-18 05:06
        • Winnonlin AUMC_TAU and othersmittyri 2017-01-18 18:00
  • WinNonlin: NCA of multiple dosing plasma PK profile mittyri 2017-01-16 17:29