WinNonlin: NCA of multiple dosing plasma PK profile [Software]

posted by mittyri – Russia, 2017-01-16 18:29 (2628 d 21:01 ago) – Posting: # 16957
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Dear Bob,

❝ I am primarily concerned about parameters including terminal t1/2, AUClast & inf, CL, MRT, Vss? I believe I cannot subtract baseline value from all the samples as commonly done in case of endogenously produced molecules and therefore all the listed parameters except t1/2 may not accurately represent drug profile.


Some pages from my bookmarks marked as must read each time before MD study performed/analyzed:-D:
Statistics in multiple dose study
half-life in multiple-dosed steady-state BE/BA study?

Kind regards,
Mittyri

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