Bioequivalence and Bioavailability Forum

WinNonlin: NCA of multiple dosing plasma PK profile [Software]

posted by mittyri – Russia, 2017-01-16 18:29 (2656 d 03:45 ago) – Posting: # 16957
Views: 11,292

Dear Bob,

❝ I am primarily concerned about parameters including terminal t1/2, AUClast & inf, CL, MRT, Vss? I believe I cannot subtract baseline value from all the samples as commonly done in case of endogenously produced molecules and therefore all the listed parameters except t1/2 may not accurately represent drug profile.

Some pages from my bookmarks marked as must read each time before MD study performed/analyzed:
Statistics in multiple dose study
half-life in multiple-dosed steady-state BE/BA study?

Complete thread:

• WinNonlin: NCA of multiple dosing plasma PK profile bobmarlo 2017-01-15 17:22 
  • WinNonlin: steady state setup Helmut 2017-01-16 13:15
    • WinNonlin: steady state setup BE-proff 2017-01-17 07:54
      • Accumulation Helmut 2017-01-18 02:22
    • WinNonlin: steady state setup bobmarlo 2017-01-17 20:36
      • NCA agrees with PK-modeling Helmut 2017-01-18 01:41
        • NCA agrees with PK-modeling bobmarlo 2017-01-18 05:06
        • Winnonlin AUMC_TAU and others mittyri 2017-01-18 18:00
  • WinNonlin: NCA of multiple dosing plasma PK profilemittyri 2017-01-16 17:29