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RegisterOnly RR is used [Design Issues]
posted by Helmut 
– Vienna, Austria, 2016-11-11 21:52 (2715 d 18:32 ago) – Posting: # 16798
Views: 4,983
Hi Astea,
For the EMA (also fashionable in Russia) only the reference’s data are used anyway. Use the same fixed effect model with sequence+subject(sequence)+period like in the Q&A-document. Doesn’t matter that we have four sequences instead of two.
For the FDA it should be possible as well but see the end of this post.
❝ If we deal with 2x4x4 of the kind TRRT|RTTR|TTRR|RRTT what variance should be used for scaling approach?
For the EMA (also fashionable in Russia) only the reference’s data are used anyway. Use the same fixed effect model with sequence+subject(sequence)+period like in the Q&A-document. Doesn’t matter that we have four sequences instead of two.
For the FDA it should be possible as well but see the end of this post.
—
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Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Any post about difference between 4x4 and 4x2 in bioequivalence studies? Mauricio Sampaio 2016-11-03 18:54
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Not more than 2 sequences in full replicates Helmut 2016-11-03 19:38
- Not more than 2 sequences in full replicates Astea 2016-11-04 08:22
- Only RR is usedHelmut 2016-11-11 20:52
- Not more than 2 sequences in full replicates Mauricio Sampaio 2016-11-11 18:39
- Not more than 2 sequences in full replicates Astea 2016-11-04 08:22
- Not more than 2 sequences in full replicates Helmut 2016-11-03 19:38
Ing. Helmut Schütz