Bioequivalence and Bioavailability Forum • PROC GLM fixes Subject

PROC GLM fixes Subject [🇷 for BE/BA]

posted by mittyri – Russia, 2016-11-05 00:00 (2722 d 11:15 ago) – Posting: # 16774
Views: 19,506

Dear Kumar,

I would cite one of our Gurus:
You will also see that in FDA's code for 222BE which is based on PROC GLM there is a random statement pertaining to subject. One should think this means we are now asking PROC GLM to add a random effect (and thus to analyse as a mixed model), perhaps. It doesnt, though. PROC GLM with the random statement for subject still treats subject as a fixed effect. The bogus statement achieves another goal and compares sequence against the subject MS

*--- GLM evaluation, output of T-R;

ODS output estimates=_est;

title "&file - GLM evaluation";

ods exclude  ExpectedMeanSquares;

Proc GLM data=PKmetric;

  class trt per seq subj;

  model logvar=trt per seq subj(seq)/CLparm alpha=&al2;

  random subj(seq)/test;

  estimate 'T-R' trt -1 1;

run; quit;



*--- back-transformation;

title "&file - &Ominus2al.% confidence intervals, back-transformed";

data _est;

  set _est;

  pe=exp(estimate);

  lower=exp(lowerCL);

  upper=exp(upperCL);

run;

Seems to be odd but here Subject is still fixed as ElMaestro wrote. So the experts are right (and ElMaestro too :-D

)

—
Kind regards,
Mittyri

Complete thread:

R code for analyzing classical 2X2 crossover designed bioequivalence data lizhao 2016-01-22 00:13
- R code for analyzing classical 2X2 crossover designed bioequivalence data ElMaestro 2016-01-22 00:59
  - R code for analyzing classical 2X2 crossover designed bioequivalence data lizhao 2016-01-22 01:26
    - On random effects and bogus statements ElMaestro 2016-01-22 12:13
      - FDA 'own' SAS code for 2x2 d_labes 2016-01-27 09:57
        
        FDA 'own' SAS code for 2x2 nobody 2016-01-27 10:09
        
        OT: PM to ElMaestro Helmut 2016-01-27 13:39
        On coffee and such... ElMaestro 2016-01-27 13:47
      - Geometric means ± SD Helmut 2016-01-27 13:51
        
        Geometric means ± SD nobody 2016-01-27 15:20
        
        Money makes the world go ’round Helmut 2016-01-27 16:11
        
        Money makes the world go ’round nobody 2016-01-27 16:31
        
        Fixed or random effect kumarnaidu 2016-11-04 14:05
        
        PROC GLM fixes Subjectmittyri 2016-11-04 23:00
        
        PROC GLM fixes Subject kumarnaidu 2016-11-05 05:22
        
        PROC GLM fixes Subject mittyri 2016-11-05 10:13
        
        PROC GLM fixes Subject kumarnaidu 2016-11-07 06:24
        
        PROC GLM fixes Subject mittyri 2016-11-07 11:57
        
        PROC GLM fixes Subject kumarnaidu 2016-11-07 12:42
        
        Geometric means ± SD Ben 2016-11-08 21:20
        
        Misunderstanding Helmut 2016-11-09 15:29
        
        Misunderstanding Ben 2016-11-14 19:40
        
        RTFM Helmut 2016-11-14 21:50