Bioequivalence and Bioavailability Forum • multiple-dosed study with bear

multiple-dosed study with bear [🇷 for BE/BA]

posted by VStus – Poland, 2016-10-11 11:01 (2751 d 04:47 ago) – Posting: # 16715
Views: 12,319

Dear Yung-jin Lee,

I'm finally back to the topic of multiple dose studies in bear. I've switched locale of error messages to English, so there will be no translation errors.

So yes, with the config I assume to be correct for multiple-dose study and standard Lambda_z assessment:


 -----------------  Current settings ----------------



                Methods                                     Setting

                 ------                                      ------

          study design?                             2x2x2 crossover

            dosing type                               multiple dose

     <U+03BB>z estimate                            adj. R sq. (ARS)

        trapezoidal AUC                          linear-up/log-down

   BE criterion (LL, %)                                          80

             dose (mg)?                                          10

                 ------                                      ------

        dosing interval                                          24

                  Tlast                                         168

                 ------                                      ------

 drug plasma conc. unit                                       ng/mL

I'm getting the same error:


Warning: Next to save all linear regression plots for λz estimation.

 It may take a while to finish. Press Enter to proceed...

Error in R.split[[j]] : subscript out of bounds

So, I change setup to select points manually and stuck with another issue: blank graph.
[image]

And, finally, error and halt of bear when I select stop for the graph:

****************************************************************************

 Data for the Ref. Products:                                                

----------------------------------------------------------------------------

 Cmax_ss, Tmax_ss, AUC(tau)ss, ln(Cmax_ss), ln(AUC(tau)ss), T1/2(z),  

  Vd/F, MRT, λz, Cl/F, Cav and Fluctuations will be calculated.

                                                                            

****************************************************************************

Waiting to confirm page change...

Error in setNames(data.frame(data), value.name) : 

  'names' attribute [1] must be the same length as the vector [0]

It worked for me somehow previously (maybe previous version of bear?). Maybe I'll dig into the code to just avoid estimation of elimination parameters for multiple dose studies?

Thank you very much in advance!
I use bear from time to time for my work and it's very helpful!

Regards, VStus

Complete thread:

Difficulties with NCA BEAR PK_Lover 2014-11-21 00:28
- Difficulties with NCA BEAR yjlee168 2014-11-21 07:34
  - Difficulties with NCA BEAR PK_Lover 2014-11-22 00:07
    - Difficulties with NCA BEAR yjlee168 2014-11-22 03:21
      - Difficulties with NCA BEAR PK_Lover 2014-11-22 09:47
        
        help test NCA BEAR yjlee168 2014-12-01 08:13
        
        help test NCA BEAR Emrah Soner Özdeş 2015-01-15 14:37
        
        help test NCA BEAR Jam 2015-01-23 08:55
        
        CSV files with a comma at the end of each line? yjlee168 2015-01-25 04:35
      - Difficulties with NCA BEAR xtianbadillo 2016-09-15 22:44
        
        old bear and friends yjlee168 2016-09-16 09:42
        
        old bear and friends VStus 2016-09-26 13:30
        
        multiple-dosed study with bear yjlee168 2016-09-26 18:04
        
        multiple-dosed study with bearVStus 2016-10-11 09:01
        
        multiple-dosed study with bear yjlee168 2016-10-11 10:15
        
        multiple-dosed study with bear VStus 2016-10-11 10:37
        multiple-dosed study with bear VStus 2016-10-12 10:37
        
        multiple-dosed study with bear [solved] yjlee168 2016-10-12 18:42