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Registerit seems possible for me... [PK / PD]
posted by yjlee168 
– Kaohsiung, Taiwan, 2016-09-24 22:19 (2769 d 08:42 ago) – Posting: # 16670
Views: 16,401
Dear mittyri and Elmaestro,
If we re-arrange the equation of
No need to know MIT (or tlag and ka). Again we can also re-arrange
We can get the values of all parameters (Dose, AUC0-infinity, AUMC0-infinity and MRT) on the right-hand sided both equations after NCA. So I wonder why we can not calculate Vss.
If we re-arrange the equation of
Vss = (dosepo x F x AUMC0-infinity) / AUC20-infinity as Vss/F = (dosepo x AUMC0-infinity) / AUC20-infinity. For extravascular dosing, we only can calculate Vc/F, Vss/F, or Cl/F.❝ ... we need to know MIT,..., tlag and ka
No need to know MIT (or tlag and ka). Again we can also re-arrange
Vss = (F x Dose/AUC0-infinity)x MRT as Vss/F = (Dose/AUC0-infinity)x MRT = Cl x MRT.We can get the values of all parameters (Dose, AUC0-infinity, AUMC0-infinity and MRT) on the right-hand sided both equations after NCA. So I wonder why we can not calculate Vss.
—
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
Complete thread:
- volume of distribution at steady state martin 2011-10-18 07:49
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Vss d_labes 2011-10-18 11:36
- History Helmut 2011-10-18 16:02
- History javier 2016-09-21 16:47
- Amazon? Yes. yjlee168 2016-09-22 11:30
- Gold Letters d_labes 2016-09-22 12:09
- Gold Letters yjlee168 2016-09-24 20:26
- Another quest mittyri 2016-09-25 15:04
- TopFit: 16bit DOS-application Helmut 2016-09-25 23:41
- TopFit: less than 1.44 MB mittyri 2016-09-26 00:02
- TopFit: less than 1.44 MB Helmut 2016-09-26 00:17
- TopFit: less than 1.44 MB ElMaestro 2016-09-26 09:43
- TopFit: less than 1.44 MB Helmut 2016-09-26 00:17
- TopFit: 16bit DOS-application yjlee168 2016-09-26 00:18
- TopFit: less than 1.44 MB mittyri 2016-09-26 00:02
- TopFit: 16bit DOS-application Helmut 2016-09-25 23:41
- Another quest mittyri 2016-09-25 15:04
- Gold Letters yjlee168 2016-09-24 20:26
- Gold Letters d_labes 2016-09-22 12:09
- Amazon? Yes. yjlee168 2016-09-22 11:30
- History javier 2016-09-21 16:47
- History Helmut 2011-10-18 16:02
- volume of distribution at steady state ElMaestro 2016-09-23 23:13
- Vss: MIT is needed anyway... mittyri 2016-09-24 00:38
- it seems possible for me...yjlee168 2016-09-24 20:19
- Leslie disagrees mittyri 2016-09-24 21:33
- OK! we cannot calculate Vdss with dataset from extravascular dosing alone yjlee168 2016-09-25 23:27
- MRTINF includes Mean Input Time mittyri 2016-09-25 23:45
- “Gravity Duration” Helmut 2016-09-25 23:47
- OK! we cannot calculate Vdss with dataset from extravascular dosing alone yjlee168 2016-09-25 23:27
- Leslie disagrees mittyri 2016-09-24 21:33
- Was Leslie wrong about Eq (8)? yjlee168 2016-09-26 00:13
- Leslie cannot be wrong mittyri 2016-09-26 00:23
- it seems possible for me...yjlee168 2016-09-24 20:19
- Vss: MIT is needed anyway... mittyri 2016-09-24 00:38
- Vss d_labes 2011-10-18 11:36
Ing. Helmut Schütz