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RegisterCalculation of PK parameters Cmax1, AUC0-tmax1,Tmec, OT0-12, AUC0-Tmec [Software]
Dear All,
How to calculate PK parameters Cmax1, AUC0-tmax1,Tmec (Time to minimum effective concentration Range of 6-10 ug/mL within the first 60 minutes), OT0-12, AUC0-Tmec in Phoenix WinNonlin 6.4. Please suggest for following data
Edit: Category changed; see also this post #1. Tabulators changed to spaces and BBcoded; see also this post #6. [Helmut]
How to calculate PK parameters Cmax1, AUC0-tmax1,Tmec (Time to minimum effective concentration Range of 6-10 ug/mL within the first 60 minutes), OT0-12, AUC0-Tmec in Phoenix WinNonlin 6.4. Please suggest for following data
Subject Period Time(hr) Concen(ug/mL)
1 1 0.00 0.00
1 1 0.25 9.07
1 1 0.50 16.10
1 1 0.75 19.90
1 1 1.00 15.10
1 1 1.50 11.00
1 1 2.00 11.20
1 1 2.50 6.81
1 1 3.00 6.18
1 1 4.00 3.47
1 1 4.25 6.66
1 1 4.50 11.40
1 1 5.00 16.90
1 1 5.50 16.20
1 1 6.00 10.70
1 1 6.50 10.90
1 1 7.00 6.76
1 1 8.00 5.02
1 1 8.25 4.12
1 1 8.50 6.65
1 1 9.00 15.90
1 1 9.50 16.40
1 1 10.00 12.50
1 1 11.00 7.63
1 1 12.00 5.11
1 1 16.00 1.40
1 1 20.00 0.00
1 1 24.00 0.00
1 2 0.00 0.00
1 2 0.25 3.48
1 2 0.50 7.21
1 2 0.75 8.36
1 2 1.00 11.30
1 2 1.50 10.80
1 2 2.00 11.10
1 2 2.50 10.70
1 2 3.00 8.20
1 2 4.00 6.17
1 2 4.25 6.13
1 2 4.50 5.59
1 2 5.00 5.16
1 2 5.50 5.55
1 2 6.00 3.95
1 2 6.50 4.14
1 2 7.00 3.94
1 2 8.00 3.77
1 2 8.25 3.83
1 2 8.50 4.46
1 2 9.00 3.87
1 2 9.50 4.24
1 2 10.00 4.43
1 2 11.00 5.84
1 2 12.00 9.90
1 2 16.00 6.52
1 2 20.00 3.37
1 2 24.00 1.46
1 3 0.00 0.00
1 3 0.25 0.00
1 3 0.50 0.60
1 3 0.75 3.91
1 3 1.00 5.10
1 3 1.50 6.46
1 3 2.00 8.01
1 3 2.50 7.97
1 3 3.00 6.56
1 3 4.00 12.30
1 3 4.25 11.10
1 3 4.50 12.30
1 3 5.00 15.40
1 3 5.50 18.20
1 3 6.00 20.00
1 3 6.50 14.70
1 3 7.00 14.90
1 3 8.00 10.50
1 3 8.25 11.30
1 3 8.50 11.30
1 3 9.00 9.93
1 3 9.50 8.55
1 3 10.00 7.17
1 3 11.00 4.58
1 3 12.00 3.77
1 3 16.00 0.96
1 3 20.00 0.00
1 3 24.00 0.00
2 1 0.00 0.00
2 1 0.25 0.00
2 1 0.50 0.00
2 1 0.75 0.00
2 1 1.00 0.00
2 1 1.50 2.32
2 1 2.00 5.23
2 1 2.50 11.10
2 1 3.00 16.30
2 1 4.00 33.50
2 1 4.25 38.30
2 1 4.50 36.70
2 1 5.00 34.70
2 1 5.50 25.90
2 1 6.00 28.60
2 1 6.50 20.70
2 1 7.00 20.90
2 1 8.00 12.10
2 1 8.25 12.20
2 1 8.50 9.52
2 1 9.00 7.38
2 1 9.50 5.97
2 1 10.00 5.65
2 1 11.00 4.41
2 1 12.00 3.15
2 1 16.00 0.99
2 1 20.00 0.00
2 1 24.00 0.00
2 2 0.00 0.00
2 2 0.25 5.06
2 2 0.50 11.30
2 2 0.75 14.20
2 2 1.00 18.90
2 2 1.50 17.80
2 2 2.00 16.90
2 2 2.50 16.40
2 2 3.00 16.90
2 2 4.00 12.70
2 2 4.25 14.40
2 2 4.50 13.90
2 2 5.00 10.30
2 2 5.50 10.20
2 2 6.00 12.40
2 2 6.50 13.00
2 2 7.00 7.63
2 2 8.00 6.77
2 2 8.25 7.53
2 2 8.55 8.32
2 2 9.00 7.38
2 2 9.50 7.15
2 2 10.00 8.40
2 2 11.00 11.60
2 2 12.00 15.10
2 2 16.00 5.61
2 2 20.00 2.22
2 2 24.00 1.00
2 3 0.00 0.00
2 3 0.25 6.79
2 3 0.50 18.00
2 3 0.75 20.10
2 3 1.00 19.90
2 3 1.50 17.10
2 3 2.00 15.50
2 3 2.50 11.70
2 3 3.00 9.88
2 3 4.00 8.18
2 3 4.25 17.00
2 3 4.50 24.00
2 3 5.00 25.10
2 3 5.50 21.00
2 3 6.00 20.20
2 3 6.50 16.30
2 3 7.00 11.80
2 3 8.00 8.13
2 3 8.25 5.92
2 3 8.50 8.41
2 3 9.00 21.30
2 3 9.50 18.90
2 3 10.00 18.60
2 3 11.00 13.20
2 3 12.00 10.60
2 3 16.00 2.93
2 3 20.00 0.93
2 3 24.00 0.00Edit: Category changed; see also this post #1. Tabulators changed to spaces and BBcoded; see also this post #6. [Helmut]
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Regards,
MGR
Regards,
MGR
Complete thread:
- Calculation of PK parameters Cmax1, AUC0-tmax1,Tmec, OT0-12, AUC0-TmecMGR 2016-08-17 07:43
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
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Ing. Helmut Schütz