Strategies to establish the BE changing the physiological behavior [Study Per­for­mance]

posted by Dr_Dan  – 2016-06-29 18:01 (1507 d 21:10 ago) – Posting: # 16460
Views: 3,291

Dear Mauricio
If you regard a BE Study as an in-vivo quality test to detect supposed differences in formulations (and which needs not to reflect clinical practice) then I think it should be possible to change the phisiological behavior to measure a principal analyte in appropriate biological fluid and compare the bioavailabilities of two formulations. As long as the BE studies is designed in such way that the formulation effect can be distinguished from other effects it should work.
I hope this helps

Kind regards and have a nice day
Dr_Dan

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