Bioequivalence and Bioavailability Forum • Quantification of S-amlodipine

Quantification of S-amlodipine [PK / PD]

posted by Mauricio Sampaio – Brazil, 2016-06-09 23:48 (2875 d 16:18 ago) – Posting: # 16422
Views: 7,338

Hi Helmut and all members who contributed.

❝ I incorrectly assumed that you have a chiral method. Sorry.

No problem my friend!

❝ Validate the method with the racemate but state in the protocol that you will correct all concentrations once you have the l-enantiomer. Analyze the study samples with the racemate standards / QCs. This is a last resort - better than to wait for the enantiomer standard and risk that the samples degrade in the meantime. Avoid it in the future.

There is still time!!! :-D

Thank you so much! Now I understood that calibrators prepared and quality control samples concentration will not be accurate. Because weighing of standard is a racemate! So, concentration of unknown samples will be inaccurate. ;-)

S-Amlodipine, let's go! :cool:

Complete thread:

Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2015-10-07 00:24
- Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2016-06-03 22:33
  - Quantification of S-amlodipine Mauricio Sampaio 2016-06-06 16:19
    - Quantification of S-amlodipine Helmut 2016-06-06 20:23
      - Quantification of S-amlodipine nobody 2016-06-07 08:29
        
        Quantification of S-amlodipine Mauricio Sampaio 2016-06-07 18:35
        
        Quantification of S-amlodipine Helmut 2016-06-08 01:32
        
        Quantification of S-amlodipineMauricio Sampaio 2016-06-09 21:48
- Linear Pharmacokinetics of Levamlodipine martin 2016-06-09 15:22
  - Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2016-06-09 22:03
    - Linear Pharmacokinetics of Levamlodipine martin 2016-06-12 21:48