Bioequivalence and Bioavailability Forum • Quantification of S-amlodipine

Quantification of S-amlodipine [PK / PD]

posted by Mauricio Sampaio – Brazil, 2016-06-06 18:19 (3650 d 14:45 ago) – Posting: # 16402
Views: 10,531

Dear,

Amlodipine is a racemic mixture of [-]S and [+]R-enantiomeric forms, with the S-amlodipine, also known as Levamlodipine, having analgesic activity.
Considering the main objective in bioanalysis will be development an achiral method, simple, sensitive, rapid and reliable mass spectrometry for the quantification of S-amlodipine in human plasma. I ask you,...can I use Amlodipine (racemic) instead of S-amlodipine (enantiomeric form) as analitical standard?

Note: The volunteers just will administrate Levamlodipine.

Complete thread:

Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2015-10-07 00:24 [PK / PD]
- Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2016-06-03 22:33
  - Quantification of S-amlodipineMauricio Sampaio 2016-06-06 16:19
    - Quantification of S-amlodipine Helmut 2016-06-06 20:23
      - Quantification of S-amlodipine nobody 2016-06-07 08:29
        
        Quantification of S-amlodipine Mauricio Sampaio 2016-06-07 18:35
        
        Quantification of S-amlodipine Helmut 2016-06-08 01:32
        
        Quantification of S-amlodipine Mauricio Sampaio 2016-06-09 21:48
- Linear Pharmacokinetics of Levamlodipine martin 2016-06-09 15:22
  - Linear Pharmacokinetics of Levamlodipine Mauricio Sampaio 2016-06-09 22:03
    - Linear Pharmacokinetics of Levamlodipine martin 2016-06-12 21:48