comparative bio­avail­ability [General Sta­tis­tics]

posted by hirenpharm – Ahmedabad, 2016-04-15 21:41 (2925 d 07:23 ago) – Posting: # 16207
Views: 4,774

Hi Helmut,

Can you please suggest when to use TOST (two one sided t-tests) for comparative bio availability in stead of a standard ANOVA approach using period, treatment, subjects as random effects? I was reading through
https://sphhp.buffalo.edu/content/dam/sphhp/biostatistics/Documents/techreports/UB-Biostatistics-TR1107.pdf
And also-
two one-sided tests” (TOST) proposed by Schuirmann (1987)

http://www.ncss.com/wp-content/themes/ncss/pdf/Procedures/PASS/Equivalence_Tests_for_Two_Means_using_Differences.pdf
—
Dr. Hiren Mehta

Complete thread:

UA Flag
Activity
 Admin contact
22,987 posts in 4,824 threads, 1,669 registered users;
88 visitors (0 registered, 88 guests [including 4 identified bots]).
Forum time: 05:05 CEST (Europe/Vienna)

The only way to comprehend what mathematicians mean by Infinity
is to contemplate the extent of human stupidity.    Voltaire

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5