Bioequivalence and Bioavailability Forum • RTFM‼

RTFM‼ [🇷 for BE/BA]

posted by BE-proff – 2016-04-10 15:42 (2937 d 22:42 ago) – Posting: # 16178
Views: 8,045

Hi Helmut,

I am not a troll :)
Below is a TOST example for calculation of parallel design study.

sampleN.TOST(CV=0.23, design="parallel")



+++++++++++ Equivalence test - TOST +++++++++++

            Sample size estimation

-----------------------------------------------

Study design:  2 parallel groups 

log-transformed data (multiplicative model)



alpha = 0.05, target power = 0.8

BE margins        = 0.8 ... 1.25

Null (true) ratio = 0.95,  CV = 0.23



Sample size (total)

 n     power

46   0.802730

What word must be written instead of "parallel" for calculate sample for steady state study?

Complete thread:

PowerTOST for steady state BE-proff 2016-04-06 21:39
- PowerTOST for steady state d_labes 2016-04-07 10:54
  - PowerTOST for steady state BE-proff 2016-04-07 15:42
    - RTFM Helmut 2016-04-07 16:09
      - RTFM BE-proff 2016-04-09 20:15
        
        RTFM‼ Helmut 2016-04-10 00:50
        
        RTFM‼BE-proff 2016-04-10 13:42
        
        RTFM‼ Helmut 2016-04-10 13:48
        
        RTFM‼ BE-proff 2016-04-12 13:36