AUC0-tau at steady state [NCA / SHAM]

posted by BNR – US, 2016-03-31 21:43  – Posting: # 16161
Views: 8,349

(edited by BNR on 2016-03-31 22:52)

Hi John,

Thank you for your reply. I thought AUC0-tau not reported by Phoenix is because Lambda can't be calculated. I tested a simulated dataset for which the Lambda can be calculated. In this case, AUC0-tau is reported by Phoenix even though the actual sampling time 23.8 is used.
Please see two example datasets below. AUC0-tau (tau=24 hr) is not reported by Phoenix for the dataset 1. But it is reported for the dataset 2. For dataset 1, AUC0-tau will be reported by Phoenix if using the nominal time 24 hr. Would you recommend to use the actual sampling time of 23.8 hr with a missing AUCo-tau value or use the nominal time of 24 hr (which is not much different from the actual time in this case) and have a calculable AUC0-tau?

Thanks.

Data set 1   Data set 2
Time  Conc   Time  Conc
 0    1000    0    1000
 4    1500    4    1500
 8     900    8    1750
12    1750   12    1750
16    1000   16    1000
23.8   800   23.8   800



Edit: Data BBcoded & full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]

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