Bioequivalence and Bioavailability Forum

ABEL sample size: more power! (joke) [🇷 for BE/BA]

posted by mittyri – Russia, 2016-03-28 23:54 (2948 d 18:26 ago) – Posting: # 16149
Views: 11,329

Hi Helmut and Astea,

"Dear volunteers of the sequence 2 (TRTR), please take some grapefruit juice before dosing on period 4"



Assumptions:
Power: at least 90%
Alpha: 0.025%
CVWR: as low as possible
CVWT: as much as possible
GMR: no better than 90%

And you don't have any profit from ABEL!

Complete thread:

• PowerTOST sample size EMA full replicate Shuanghe 2016-03-07 18:04 
  • merciless tester! Helmut 2016-03-07 18:56
  • PowerTOST sample size EMA full replicate yjlee168 2016-03-07 20:15
  • Merciless peer reviewers d_labes 2016-03-08 08:50
  • PowerTOST V1.3-4 d_labes 2016-03-09 18:43
  • PowerTOST sample size EMA full replicate Astea 2016-03-24 19:34
    • RSABE is not bijective (lengthy answer) Helmut 2016-03-25 14:23
      • RSABE is not bijective (lengthy answer) Astea 2016-03-27 21:07
        • ABEL sample size examples Helmut 2016-03-28 00:42
          • ABEL sample size: more power! (joke)mittyri 2016-03-28 21:54