Science fiction [Two-Stage / GS Designs]
nearly one year ago ElMaestro wrote:
❝ Combining 2-stage and replicated studies in one protocol is hitherto undescribed in the scientific literature. So you likely do not know how the type I error is controlled or how your method performs in terms of power/sample sizes. If the agency asks you to give proof that the Type I Error is controlled you might be somewhat doomed?
❝ There appears to me to be no reason why it wouldn't work, though. It just needs to be investigated and reported
and Helmut:
❝ A lot of problems. I agree with ElMaestro.
❝ ❝ Is it possible?
❝ Not yet – unless you have access to a massive-parallel supercomputer... I made a quick estimation (I have a very fast workstation): ~60 years running 24/7…
My question for today: is this still the case/state of science that you can not combine 2-stage and replicate designs?
A short update would be very much apreciated. In case that there is new literature available I would love if you could give references.
Thanks for your comments in advance.
Kind regards
Dr_Dan
Kind regards and have a nice day
Dr_Dan
Complete thread:
- Replicated 4×2 and two-stage-design, in the same protocol Mauricio Sampaio 2015-04-06 08:37
- Replicated 4×2 and two-stage-design, in the same protocol ElMaestro 2015-04-06 08:53
- Science fiction Helmut 2015-04-06 14:20
- Science fictionDr_Dan 2016-03-04 10:33
- mindblowing ElMaestro 2016-10-11 07:44
- Natural constant as usual; not for reference-scaling Helmut 2016-10-11 09:50
- Consistency DavidManteigas 2016-10-11 11:25
- Natural constant as usual; not for reference-scaling Helmut 2016-10-11 09:50