0.00 concentration value between two measurable concentrations [NCA / SHAM]

posted by arl_stat – India, 2016-03-02 09:13  – Posting: # 16042
Views: 4,256

Hello Forum Members,

In a data, we received 0.00 concentration value between two measurable concentrations. How to handle this?
Should we exclude the 0.00 concentration value for calculation of AUC?
Also what is the regulatory requirements.

For eg:
Subj  Conc
1     0.00
1     0.00
1     0.00
1     0.00
1     0.36
1     0.00
1     0.00
1     0.00
1     0.71
1    25.79
1    99.09
1    85.30
1    66.10
1    35.62
1    12.61
1     0.00
1     0.00
1     4.69
1     3.83
1     3.12
1     2.21
1     1.81
1     1.11
1     0.73
1     0.00
1     0.25
1     0.00
1     0.00
1     0.00


Thanks.


Edit: Category changed. Can you please post sampling times instead of the subject number? [Helmut]

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