0.00 concentration value between two measurable concentrations [NCA / SHAM]

posted by arl_stat – India, 2016-03-02 11:13 (2948 d 03:35 ago) – Posting: # 16042
Views: 5,575

Hello Forum Members,

In a data, we received 0.00 concentration value between two measurable concentrations. How to handle this?
Should we exclude the 0.00 concentration value for calculation of AUC?
Also what is the regulatory requirements.

For eg:
Subj  Conc
1     0.00
1     0.00
1     0.00
1     0.00
1     0.36
1     0.00
1     0.00
1     0.00
1     0.71
1    25.79
1    99.09
1    85.30
1    66.10
1    35.62
1    12.61
1     0.00
1     0.00
1     4.69
1     3.83
1     3.12
1     2.21
1     1.81
1     1.11
1     0.73
1     0.00
1     0.25
1     0.00
1     0.00
1     0.00


Thanks.


Edit: Category changed. Can you please post sampling times instead of the subject number? [Helmut]

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,638 registered users;
90 visitors (0 registered, 90 guests [including 8 identified bots]).
Forum time: 14:49 CET (Europe/Vienna)

Nothing shows a lack of mathematical education more
than an overly precise calculation.    Carl Friedrich Gauß

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5