Bioequivalence and Bioavailability Forum • BLLOQ at first two time ponts, AUC calculation

BLLOQ at first two time ponts, AUC calculation [🇷 for BE/BA]

posted by Astea – Russia, 2016-01-30 18:11 (3000 d 16:58 ago) – Posting: # 15901
Views: 24,913

Dear yjlee168!

Please check the calculation of AUC_last in the situation when we have two zero (BLLOQ) points in concentration data. It seems to me that there are appeared an error in the latest version of BEAR. May be it is closely connected with the corrections you've made to improve data with BLLOQ in the elimination part of the curve.

Let's start with the Single2x2x2_demo: if we will change the second concentration to zero the AUC_0t would be 14451,88, that is greater on 0.25*1/2*125 from the real value: 14436,25.

Data set: "subj","seq","prd","time","conc"
1,2,2,0,0
1,2,2,0.25,0
1,2,2,0.5,125
1,2,2,0.75,567
1,2,2,1,932
and so on

AUC calculation method: 1 (all linear)

Please correct me if I'm wrong...

—
"Being in minority, even a minority of one, did not make you mad"

Complete thread:

bear v2.7.0 released yjlee168 2015-12-07 09:18
- Suggestion ElMaestro 2015-12-07 10:12
  - Suggestion yjlee168 2015-12-07 10:55
    - Suggestion Helmut 2015-12-07 14:01
      - Suggestion yjlee168 2015-12-07 18:51
- bear v2.7.0 released Astea 2015-12-10 16:36
  - if Clast is zero in bear yjlee168 2015-12-10 17:23
    - if Clast is zero in bear Astea 2015-12-10 20:50
      - if Clast is zero in bear yjlee168 2015-12-11 03:28
        
        if Clast is zero in bear Astea 2015-12-11 09:39
        
        if Clast is zero in bear yjlee168 2015-12-11 17:16
    - bear v2.7.1 yjlee168 2015-12-15 10:21
      - bear v2.7.1 Astea 2015-12-15 19:32
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
        
        BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-16 11:38
        
        BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
        
        BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
        
        BLLOQ at first two time ponts, AUC calculationAstea 2016-01-30 17:11
        
        zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
        
        BQL rules in bear mittyri 2016-02-01 22:16
        
        BQL rules in bear yjlee168 2016-02-02 10:59
        possible solutions? yjlee168 2016-02-02 21:30
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear yjlee168 2016-02-03 09:04
        
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
        
        Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
        
        error message in bear mahmoud-teaima 2016-02-09 04:55
        
        please check your dataset file yjlee168 2016-02-09 06:40
        
        please check your dataset file mahmoud-teaima 2016-02-09 15:00
        
        please check your dataset file yjlee168 2016-02-09 15:38
        
        A possible R bug? yjlee168 2016-02-09 19:14