R code for analyzing classical 2X2 crossover designed bioequivalence data [🇷 for BE/BA]

posted by lizhao – US, 2016-01-22 02:26 (2989 d 12:55 ago) – Posting: # 15843
Views: 22,024

Hi ElMaestro,

Thank you very much for your help. I do have a question about using lm() instead of lme() function in R. Based on my understanding, subject effect should be considered to be random effect:confused:? If I use lm(), all effects are treated as fixed effects. You suggest me to use lm, is it based on FDA or EMA guidance?


Another question would be related to plot mean curves of Test and Reference product. If I want to plot a mean plot (mean and error bars) of a crossover biequivalence study, should I use within-subject confidence intervals or between-subject confidence intervals? They are apparently quite different.

Thanks again!

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