BLLOQ ≠ 0 with measured drug plasma conc. [🇷 for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2015-12-15 21:17 (3025 d 13:19 ago) – Posting: # 15734
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Dear Astea,

❝ What about zero-samples that are not in the last elimination part of the curve? I mean that theoretically there can be a zero-concentration point between other non-zero values (for example for the drugs with entero-hepatic recirculation)? The result of the calculation would depend on whether this point is marked like "zero" or "NA", wouldn't it?


Good question. Well, theoretically there should be no real zero conc. at all after taking a medicine for a reasonable sampling time period of a BE/BA study. Of course, there may have some conc. below LLOQ, occurring at any time point. I don't quite understand why we will possibly have real zero conc. for the drug undergoing entero-hepatic recirculation.:confused: Are they just below LLOQ? Could you explain more? Thanks.

All the best,
-- Yung-jin Lee
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