if Clast is zero in bear [🇷 for BE/BA]

posted by yjlee168 Homepage – Kaohsiung, Taiwan, 2015-12-11 18:16 (3030 d 17:20 ago) – Posting: # 15724
Views: 27,080

Dear Astea,

❝ 1). I used linear-up/log-down method (1)

❝ 2). When 'NA' is marked for the last point BEAR gets λz in the following form (below I attach all the results for the verification):


OK. Thanks.

❝ ...

❝ And when we leave "0" and choose manual selection (three points):

»<< NCA Outputs:- <Subj.# 1 > (Ref.)>>

--------------------------------------------------------

subj  time   conc  AUC(0-t) AUMC(0-t)

...

    1  3.00 1604.0  3309.275  6495.444

    1  4.00 1460.0  4841.275 11821.444

    1  8.00  797.0  9355.275 36253.444

    1 12.00  383.0 11715.275 58197.444

    1 24.00    0.0 14013.275 85773.444 <-


The zero-Clast should not be included even using manual selection method, though it will not cause any error in bear. This is because the extrapolated AUC (i.e. AUCt-inf) will become zero (since Clast is zero). I don't think this is a correct approach. Looks like that I have to take care of this error with bear.

❝ ...

❝ It seems to me very strange that λz in BEAR are slightly different: 0.16708 and 0.16727. And the question is why the first method (that is calculating with manually selected 3 points) fails.


Oh? any error message? Thanks again.

All the best,
-- Yung-jin Lee
bear v2.9.1:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here

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