Bioequivalence and Bioavailability Forum • bear v2.7.0 released

bear v2.7.0 released [🇷 for BE/BA]

posted by Astea – Russia, 2015-12-10 17:36 (3056 d 23:02 ago) – Posting: # 15717
Views: 27,412

Dear yjlee168!

Firstly, thank you a lot for your unique program!

I've got some questions about calculations. Do I understand correctly that BEAR can calculate only AUCall but not AUClast?
What is the formula for AUCinf calculation? I guess it is like AUCinf=AUCall+C/lambda_z, where C is the observed concentration in the last point, so AUCinf is actually AUCinf_obs, based on AUCall, am I right?

Why does BEAR crash when there is a zero-concentration in the last point? (I change only one point: last point in concentrations of the first subject in the Single2x2x2 demo-data and BEAR returns:

Error in
lm.fit(x, y, offset = offset, singular.ok = singular.ok, ...) :
NA/NaN/Inf in 'y'

It allows calculation only for the manual selection of points. Thats very uncomfortably especially when we want to get primary information on the confidence intervals for AUC and Cmax. There is no need to calculate lambda_z and AUCinf if we just want to calculate AUC and Cmax...

—
"Being in minority, even a minority of one, did not make you mad"

Complete thread:

bear v2.7.0 released yjlee168 2015-12-07 09:18
- Suggestion ElMaestro 2015-12-07 10:12
  - Suggestion yjlee168 2015-12-07 10:55
    - Suggestion Helmut 2015-12-07 14:01
      - Suggestion yjlee168 2015-12-07 18:51
- bear v2.7.0 releasedAstea 2015-12-10 16:36
  - if Clast is zero in bear yjlee168 2015-12-10 17:23
    - if Clast is zero in bear Astea 2015-12-10 20:50
      - if Clast is zero in bear yjlee168 2015-12-11 03:28
        
        if Clast is zero in bear Astea 2015-12-11 09:39
        
        if Clast is zero in bear yjlee168 2015-12-11 17:16
    - bear v2.7.1 yjlee168 2015-12-15 10:21
      - bear v2.7.1 Astea 2015-12-15 19:32
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
        
        BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
        
        BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-16 11:38
        
        BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
        
        BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
        
        BLLOQ at first two time ponts, AUC calculation Astea 2016-01-30 17:11
        
        zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
        
        BQL rules in bear mittyri 2016-02-01 22:16
        
        BQL rules in bear yjlee168 2016-02-02 10:59
        possible solutions? yjlee168 2016-02-02 21:30
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear yjlee168 2016-02-03 09:04
        
        zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
        
        Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
        
        error message in bear mahmoud-teaima 2016-02-09 04:55
        
        please check your dataset file yjlee168 2016-02-09 06:40
        
        please check your dataset file mahmoud-teaima 2016-02-09 15:00
        
        please check your dataset file yjlee168 2016-02-09 15:38
        
        A possible R bug? yjlee168 2016-02-09 19:14