Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Back to the forum  2018-06-22 19:21 CEST (UTC+2h)

bear v2.7.0 released [R for BE/BA]

posted by yjlee168 Homepage - Kaohsiung, Taiwan, 2015-12-07 09:18  - Posting: # 15699
Views: 17,090

(edited by yjlee168 on 2015-12-07 11:14)

Dear all,

I have released bear v2.7.0 to sourceforge. One minor change in this release is to check all dataset first to make sure that all subjects' λz (terminal-phase elimination rate constant, or 'ke' or 'kel') can be calculated before going to NCA, based on selected λz calculation method (ARS, AIC, TTT, TTTARS or TTTAIC). This error has been reported by some users (such as here and here). The error messages are something like Error in NAToUnknown.default(x = ke, unknown = 0) : 'x' already has value “0”

Basically, ARS or AIC uses the same criteria to check the dataset (OK if > 2 data points after Tmax). TTT and its combination forms use the criteria of "OK if > 2 data points after 2*Tmax". The not-OK subject's data will be listed on R console/terminal. If there is any subject found not meet the criteria of selected λz, bear will be aborted and go back to the top menu. If this is the case, users need to decide to (i) change the λz calculation method (manual selection?); or (ii) consider to delete the entire subject from dataset if necessary.

That's it and thank you for reading.

Ps. The dataset checking function was built inside the original codes (not on the menu list); so if the dataset is OK, bear continues as usual. [added after OP]

All the best,
---Yung-jin Lee
[image]bear v2.8.3:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan
Download link (updated) -> here

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,418 posts in 3,912 threads, 1,173 registered users;
online 15 (0 registered, 15 guests [including 5 identified bots]).

The greatest shortcoming of the human race is our inability
to understand the exponential function.    Albert Bartlett

BEBAC Ing. Helmut Schütz