An other one with 0.0304 [Two-Stage / GS Designs]

posted by Helmut Homepage – Vienna, Austria, 2015-12-03 17:26 (3038 d 15:35 ago) – Posting: # 15697
Views: 11,891

Dear Detlew,

❝ I have another one:

Gould A. L.

"Group Sequential Extensions of a Standard Bioequivalence Testing Procedure"

❝ Journal of Pharmacokinetics and Biopharmaceutics. Vol 23. No.1. 1995

❝ Table I: critical value for n1=n2: 1.8753


How could I forget Mr Gould? He was first in exploring this stuff for BE-studies.

rep(1-pnorm(1.8753), 2)
[1] 0.03037573 0.03037573

BTW, in the late 1990s I tried his method (scientific advices in France and Germany). Both didn’t accept it. :-(

❝ That means on the other hand: Potvin und Konsorten were much more lucky then they should have been.


Yep. Lucky punch.

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