Pre-dose concentration found higher than preceding sample [Bioanalytics]

posted by Mitesh Panchal – India, 2015-08-30 06:54 (3134 d 03:14 ago) – Posting: # 15363
Views: 5,471

Hello Everyone,

I have faced following issue,

I have found concentration in pre-dose sample and that concentration is higher than last sample / time point of Period 01 (i.e. P02, pre-dose concentration is higher than its preceding sample).

In such case we need to repeat the sample (i have repeated sample).

My doubt is,

If i found repeated value different from initial value then what to do? we need to accept which value??? (Initial / Repeated / we need to reported as NR)


eg.

Initial Value - 251 ng / mL
Repeated Value - 0.oo ng / mL (totally different value)

Please give me your suggestions.

Regards,
Mitesh Panchal

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