volume of distribution at steady-state [PK / PD]
Dear all,
I am struggling with an apparently simple problem, probably someone can clear my mind.
I have PK data following IV and IP administration. Concentrations following IP administration were best described by a zero-order absoprtion model. As
AUMC/AUC = MIT ("mean input time") + MRT
and for zero-order absorption MIT = absoprtion duration divided by two (=Tabs/2)
MRTIP = AUMCIP/AUCIP - Tabs/2
Further,
CLIP = F*dose/AUCIP where F is the bioavailability.
I can estimate F by AUCIP/AUCIV (same doses were administered) and subsequently CLIP which is equal to CLIV as:
CLIP = F*dose/AUCIP = dose/AUCIV = CLIV
Does it make sense to calcualte the volume of distribution at steady-state for IP administration by MRTIP*CLIP?
Thanks for your efforts,
All the best,
Alex
I am struggling with an apparently simple problem, probably someone can clear my mind.
I have PK data following IV and IP administration. Concentrations following IP administration were best described by a zero-order absoprtion model. As
AUMC/AUC = MIT ("mean input time") + MRT
and for zero-order absorption MIT = absoprtion duration divided by two (=Tabs/2)
MRTIP = AUMCIP/AUCIP - Tabs/2
Further,
CLIP = F*dose/AUCIP where F is the bioavailability.
I can estimate F by AUCIP/AUCIV (same doses were administered) and subsequently CLIP which is equal to CLIV as:
CLIP = F*dose/AUCIP = dose/AUCIV = CLIV
Does it make sense to calcualte the volume of distribution at steady-state for IP administration by MRTIP*CLIP?
Thanks for your efforts,
All the best,
Alex
Complete thread:
- volume of distribution at steady-stateAlex 2015-08-25 17:00 [PK / PD]
- volume of distribution at steady-state d_labes 2015-08-26 10:47
- volume of distribution at steady-state Alex 2015-08-26 14:05
- volume of distribution at steady-state d_labes 2015-08-26 10:47