Bioequivalence and Bioavailability Forum

upper CL < PE [Study Assessment]

posted by Helmut – Vienna, Austria, 2015-04-21 02:39 (3290 d 16:14 ago) – Posting: # 14724
Views: 11,522

Hi ElMaestro,

❝ If I am not mistaken HRotter or some other guru once mentioned on this forum that a PE outside the CI is theoretically possible;

Thomas Jaki. When he tried to explain that to me I got mental hickups. But was other stuff: The one-sided CI of a CV with an α >0.5 – which is nuts.

library(PowerTOST) CV <- 0.2 df <- 22 alpha <- 0.55 CL <- CVCL(CV=CV, df=df, side="upper", alpha=alpha) cat("CV :", CV, "\nCL of CV:", CL[1], "to", CL[2], "\n") # CV : 0.2 # CL of CV: 0 to 0.1992335

Implemented according to Chow/Liu… Beyond me.

❝ from the equation for the 90% BE CI -which I hope is generally accepted- I think it is evident that the PE is not outside the CI.

Rightyright. Not possible.

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Helmut Schütz

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Complete thread:

Study Results VSL 2015-04-20 21:46 [Study Assessment]
- Study Results ElMaestro 2015-04-20 23:47
  - upper CL < PEHelmut 2015-04-21 00:39
- PE restriction for HVDs/HVDPs; testing effects Helmut 2015-04-21 00:24
  - PE restriction for HVDs/HVDPs; testing effects jag009 2015-04-21 16:49
    - PE restriction for HVDs/HVDPs; testing effects Helmut 2015-04-21 17:12
      - PE restriction for HVDs/HVDPs; testing effects jag009 2015-04-22 15:47
        
        PE restriction for HVDs/HVDPs Helmut 2015-04-22 16:41
  - GMR outside the limits when using ABEL Averroes 2017-05-19 11:53
    - Regulations ≠ Science Helmut 2017-05-19 14:07
      - Regulations ≠ Science Averroes 2017-05-22 20:51

upper CL < PE [Study As­sess­ment]

Complete thread:

upper CL < PE [Study Assessment]