Bioequivalence and Bioavailability Forum

R vs. Phoenix & SAS? [🇷 for BE/BA]

posted by yjlee168  – Kaohsiung, Taiwan, 2015-04-20 21:36 (3291 d 07:17 ago) – Posting: # 14719
Views: 22,979

Dear Helmut,

❝ What would we need in bear?

Wow! thank you so much. But that's too much. It must be a typo. May I suggest as "what we can do with R?" There are lots of R users/gurus in this Forum.

❝ For the FDA that would be a mixed-effects model as given in the 2001 guidance and the pro­ge­sterone guidance.

I like this.

❝ For the EMA we would need an “all effects fixed” model (Method A of the Q&A).

One stupid question : if EMA needs an "all effects fixed" model, why do we use a mixed model to do analysis? I don't remember lme() right now, but lmer() must have at least a random variable. I tried lmer() last night and was pretty sure about that. Does EMA imply that we should use lm() to analyze replicate crossover dataset?

❝ • FDA – RSABE: Again the progesterone guidance.

❝ EMA – ABEL: The Q&A, Methods A & B. Crippled model to get CV_wR...

❝ I would say, that’s the target.

You should try to get funded from EMA or FDA for these projects. These are really great projects, indeed.

Complete thread:

• Bear vs. Phoenix & SAS Helmut 2015-04-20 17:34 
  • R vs. Phoenix & SAS?yjlee168 2015-04-20 19:36
    • R vs. Phoenix & SAS? Helmut 2015-04-21 01:02
      • lme() does not work with all fixed effects yjlee168 2015-04-21 23:41
        • lme() does not work with all fixed effects Astea 2016-11-04 00:13
          • lmer: Method B (PE catched for imbalanced dataset!!!) and Method C mittyri 2016-11-05 17:38
            • lmer: Method B (PE catched for imbalanced dataset!!!) and Method C Astea 2016-11-05 19:27
              • lmer: Method B is ready for scaling mittyri 2016-11-05 20:01
                • lmer: Method B is ready for scaling Astea 2016-11-06 11:50
                  • lmer: Method B is ready for scaling mittyri 2016-11-07 06:07
  • info for lsmeans yjlee168 2015-04-20 21:34
    • info for lsmeans Helmut 2015-04-21 01:15
      • once more about R and replicate designes Astea 2016-11-02 23:43
        • once more about R and replicate designes VStus 2016-11-06 11:34
          • Getting variance components from the lmer output StatR 2017-02-03 13:53
            • Getting variance components from the lmer output VStus 2017-02-03 15:47
              • Getting variance components from the lmer output StatR 2017-02-03 17:12
                • Getting variance components d_labes 2017-02-07 11:16
                  • Getting variance components StatR 2017-02-07 11:36
                  • Getting variance components StatR 2017-02-08 08:41
                    • Getting variance components d_labes 2017-02-08 10:13
                      • Getting variance components StatR 2017-02-08 10:19
                    • Data structure Helmut 2017-02-08 10:33
                      • Data structure StatR 2017-02-08 10:49