linear kinetics following infusion? [PK / PD]
Hi Alex,
you can assume anything and will know after the experiment.
Theoretically infusion rates matter. It might be that with a fast infusion rate you saturate the metabolizing enzyme(s) (high Cmax) and with a slow one (low Cmax) not. You could expect a slower elimination in the former case. However, unless you torture the enzymes in such a way that the elimination switches at high concentrations to zero-order (like C2H5OH) you could still expect ~equal AUCs (=linear PK).
Personally I don’t think you should be too worried about infusions. Such effects are more likely if comparing very fast releasing oral formulations with MR.
you can assume anything and will know after the experiment.
Theoretically infusion rates matter. It might be that with a fast infusion rate you saturate the metabolizing enzyme(s) (high Cmax) and with a slow one (low Cmax) not. You could expect a slower elimination in the former case. However, unless you torture the enzymes in such a way that the elimination switches at high concentrations to zero-order (like C2H5OH) you could still expect ~equal AUCs (=linear PK).
Personally I don’t think you should be too worried about infusions. Such effects are more likely if comparing very fast releasing oral formulations with MR.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- linear kinetics following infusion? Alex 2015-04-14 12:48
- linear kinetics following infusion?Helmut 2015-04-14 14:38