linear kinetics following infusion? [PK / PD]
Dear friends!
I am involved in the planing phase of a repeated dose TK study (pre-clincal) in which drug is administered by infusion and I am wondering whether there is a conflict regarding zero-order absorption processes and linear kinetics IF one can assume a constant infusion interval (for a given dose range)?
I want to know if it is valid to play around with different simulated scenarios (different doses, different dosing intervals, ...) on the assumption of linear kinetics AND a constant infusion interval...
Thanks a lot, as always...
Alex
I am involved in the planing phase of a repeated dose TK study (pre-clincal) in which drug is administered by infusion and I am wondering whether there is a conflict regarding zero-order absorption processes and linear kinetics IF one can assume a constant infusion interval (for a given dose range)?
I want to know if it is valid to play around with different simulated scenarios (different doses, different dosing intervals, ...) on the assumption of linear kinetics AND a constant infusion interval...
Thanks a lot, as always...
Alex
Complete thread:
- linear kinetics following infusion?Alex 2015-04-14 12:48 [PK / PD]
- linear kinetics following infusion? Helmut 2015-04-14 14:38