Bioequivalence and Bioavailability Forum • Cmax value higher than AUC

Cmax value higher than AUC [PK / PD]

posted by Dr_Dan – Germany, 2015-02-17 19:53 (3354 d 19:10 ago) – Posting: # 14444
Views: 12,807

Hi
Cmax is missing the dimension time which is needed to compare the absolute value to AUC. So you need a third variable to link AUC and Cmax. This could be t1/2.

something like:
If AUCt with t > 5*t1/2 and t1/2 > 1.5 h then AUCt>Cmax

Can anybody calculate the threshold value for t1/2? 1.5 h was just a guess.

Kind regards
Dr_Dan

—
Kind regards and have a nice day
Dr_Dan

Complete thread:

Cmax value higher than AUC msmnainar 2015-02-16 13:41
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46
  - Cmax value higher than AUC msmnainar 2015-02-16 13:51
    - Cmax value higher than AUC ElMaestro 2015-02-16 14:01
      - Cmax value higher than AUC nobody 2015-02-16 14:23
      - Cmax value higher than AUC Dr_Dan 2015-02-17 08:11
        
        Cmax value higher than AUC nobody 2015-02-17 09:38
        
        Cmax value higher than AUC janmacek 2015-02-17 10:41
        
        Cmax value higher than AUC nobody 2015-02-17 11:19
        
        Cmax value higher than AUC msmnainar 2015-02-17 11:36
        
        Magic ElMaestrolophystic RoadShow ElMaestro 2015-02-17 14:56
        
        Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
        
        Magic ElMaestrolophystic RoadShow nobody 2015-02-17 16:32
        Bizarre discussion… Helmut 2015-02-17 17:06
        
        Bizarre discussion… janmacek 2015-02-17 17:42
        
        Cmax value higher than AUCDr_Dan 2015-02-17 18:53
        
        Cmax value higher than AUC nobody 2015-02-17 20:16