Bizarre discussion… [PK / PD]
Dear Jan,
OK, but is such a comparison meaningful at all? No way. We have values, which consist of two parts: a number and a unit.
IMHO, comparing numbers whilst ignoring units doesn’t make any [sic] sense.
Some physicians notoriously “forget” units. When they tell me “The patient has a value of 37!” I use to reply “37 what? Cats? That’s a lot if he lives in a small apartment.”
There is a nice thing in physics called unit equation. Let’s go back to msmnainar’s example of Cmax 1,000 ng/mL and AUC 730 h×ng/mL. What do we mean in common language when we say sumfink is smaller than another? We calculate a difference (two apples are less than three) or a ratio (hey, T/R). In the former case the unit equation would no work at all and in the latter the result for AUC/Cmax would be 0.73 h. Gimme a break! Please don’t tell me that two apples are less than three oranges.
Another example: The orthodromic distance from Moscow to Vladivostoc is 6,434 km. Makes quite a walk. If we switch units – do you think that 0.0000000002085pc are shorter?
❝ […] the discussion was simply about comparison of two numbers, 1000 and 730.
OK, but is such a comparison meaningful at all? No way. We have values, which consist of two parts: a number and a unit.
IMHO, comparing numbers whilst ignoring units doesn’t make any [sic] sense.
Some physicians notoriously “forget” units. When they tell me “The patient has a value of 37!” I use to reply “37 what? Cats? That’s a lot if he lives in a small apartment.”
There is a nice thing in physics called unit equation. Let’s go back to msmnainar’s example of Cmax 1,000 ng/mL and AUC 730 h×ng/mL. What do we mean in common language when we say sumfink is smaller than another? We calculate a difference (two apples are less than three) or a ratio (hey, T/R). In the former case the unit equation would no work at all and in the latter the result for AUC/Cmax would be 0.73 h. Gimme a break! Please don’t tell me that two apples are less than three oranges.
Another example: The orthodromic distance from Moscow to Vladivostoc is 6,434 km. Makes quite a walk. If we switch units – do you think that 0.0000000002085pc are shorter?
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Cmax value higher than AUC msmnainar 2015-02-16 13:41
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46
- Cmax value higher than AUC msmnainar 2015-02-16 13:51
- Cmax value higher than AUC ElMaestro 2015-02-16 14:01
- Cmax value higher than AUC nobody 2015-02-16 14:23
- Cmax value higher than AUC Dr_Dan 2015-02-17 08:11
- Cmax value higher than AUC nobody 2015-02-17 09:38
- Cmax value higher than AUC janmacek 2015-02-17 10:41
- Cmax value higher than AUC nobody 2015-02-17 11:19
- Cmax value higher than AUC msmnainar 2015-02-17 11:36
- Magic ElMaestrolophystic RoadShow ElMaestro 2015-02-17 14:56
- Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
- Magic ElMaestrolophystic RoadShow nobody 2015-02-17 16:32
- Bizarre discussion…Helmut 2015-02-17 17:06
- Bizarre discussion… janmacek 2015-02-17 17:42
- Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
- Cmax value higher than AUC nobody 2015-02-17 11:19
- Cmax value higher than AUC janmacek 2015-02-17 10:41
- Cmax value higher than AUC Dr_Dan 2015-02-17 18:53
- Cmax value higher than AUC nobody 2015-02-17 20:16
- Cmax value higher than AUC nobody 2015-02-17 09:38
- Cmax value higher than AUC ElMaestro 2015-02-16 14:01
- Cmax value higher than AUC msmnainar 2015-02-16 13:51
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46