Cmax value higher than AUC [PK / PD]
Hi nobody and Dr_Dan,
i.v. bolus is not typically administered in a bioequivalence study. But if we want to compare numerically AUC (ng.h/ml) and Cmax (ng/ml), it is possible that Cmax > AUC if the kinetics after oral administration is rapid (like in prodrugs).
Consider the following example
Cmax = 100 ng/ml
AUC = 38.3 ng·h/ml
Have a nice day!
Jan
i.v. bolus is not typically administered in a bioequivalence study. But if we want to compare numerically AUC (ng.h/ml) and Cmax (ng/ml), it is possible that Cmax > AUC if the kinetics after oral administration is rapid (like in prodrugs).
Consider the following example
Time (h) Cmax
0.000 0
0.167 2
0.333 100
0.500 50
0.750 25
1.000 12.5
1.250 4
1.500 1
1.750 0
Cmax = 100 ng/ml
AUC = 38.3 ng·h/ml
Have a nice day!
Jan
Complete thread:
- Cmax value higher than AUC msmnainar 2015-02-16 13:41
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46
- Cmax value higher than AUC msmnainar 2015-02-16 13:51
- Cmax value higher than AUC ElMaestro 2015-02-16 14:01
- Cmax value higher than AUC nobody 2015-02-16 14:23
- Cmax value higher than AUC Dr_Dan 2015-02-17 08:11
- Cmax value higher than AUC nobody 2015-02-17 09:38
- Cmax value higher than AUCjanmacek 2015-02-17 10:41
- Cmax value higher than AUC nobody 2015-02-17 11:19
- Cmax value higher than AUC msmnainar 2015-02-17 11:36
- Magic ElMaestrolophystic RoadShow ElMaestro 2015-02-17 14:56
- Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
- Magic ElMaestrolophystic RoadShow nobody 2015-02-17 16:32
- Bizarre discussion… Helmut 2015-02-17 17:06
- Bizarre discussion… janmacek 2015-02-17 17:42
- Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
- Cmax value higher than AUC nobody 2015-02-17 11:19
- Cmax value higher than AUCjanmacek 2015-02-17 10:41
- Cmax value higher than AUC Dr_Dan 2015-02-17 18:53
- Cmax value higher than AUC nobody 2015-02-17 20:16
- Cmax value higher than AUC nobody 2015-02-17 09:38
- Cmax value higher than AUC ElMaestro 2015-02-16 14:01
- Cmax value higher than AUC msmnainar 2015-02-16 13:51
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46