Cmax value higher than AUC [PK / PD]

posted by janmacek – Czech Republic, 2015-02-17 11:41 (3327 d 15:29 ago) – Posting: # 14436
Views: 12,760

Hi nobody and Dr_Dan,

i.v. bolus is not typically administered in a bioequivalence study. But if we want to compare numerically AUC (ng.h/ml) and Cmax (ng/ml), it is possible that Cmax > AUC if the kinetics after oral administration is rapid (like in prodrugs).

Consider the following example

Time (h)   Cmax
0.000        0
0.167        2
0.333      100
0.500       50
0.750       25
1.000       12.5
1.250        4
1.500        1
1.750        0

Cmax = 100 ng/ml
AUC = 38.3 ng·h/ml

Have a nice day!

Jan

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