Cmax value higher than AUC [PK / PD]
Hi ElMaestro
You are right that msnaimar can not directly compare two different units on the one hand but on the other hand the question is reasonable. Is it possible that Cmax > AUCt? IMHO not. Cmax just represents one point of the curve (o.k. it is the highest) but AUC represents all points under the curve i.e. Cmax + all the rest and therefore the value for AUC must be >> as the value for Cmax provided that you use the same dimension for concentration (in our case ng/ml), right?
Please explain if I am completely wrong
Kind regards
Dr_Dan
❝ It doesn't make sense. At least not to me.
❝ AUCt is a concentration integrated over time, Cmax is a concentration.
You are right that msnaimar can not directly compare two different units on the one hand but on the other hand the question is reasonable. Is it possible that Cmax > AUCt? IMHO not. Cmax just represents one point of the curve (o.k. it is the highest) but AUC represents all points under the curve i.e. Cmax + all the rest and therefore the value for AUC must be >> as the value for Cmax provided that you use the same dimension for concentration (in our case ng/ml), right?
Please explain if I am completely wrong
Kind regards
Dr_Dan
—
Kind regards and have a nice day
Dr_Dan
Kind regards and have a nice day
Dr_Dan
Complete thread:
- Cmax value higher than AUC msmnainar 2015-02-16 13:41
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46
- Cmax value higher than AUC msmnainar 2015-02-16 13:51
- Cmax value higher than AUC ElMaestro 2015-02-16 14:01
- Cmax value higher than AUC nobody 2015-02-16 14:23
- Cmax value higher than AUCDr_Dan 2015-02-17 08:11
- Cmax value higher than AUC nobody 2015-02-17 09:38
- Cmax value higher than AUC janmacek 2015-02-17 10:41
- Cmax value higher than AUC nobody 2015-02-17 11:19
- Cmax value higher than AUC msmnainar 2015-02-17 11:36
- Magic ElMaestrolophystic RoadShow ElMaestro 2015-02-17 14:56
- Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
- Magic ElMaestrolophystic RoadShow nobody 2015-02-17 16:32
- Bizarre discussion… Helmut 2015-02-17 17:06
- Bizarre discussion… janmacek 2015-02-17 17:42
- Magic ElMaestrolophystic RoadShow janmacek 2015-02-17 16:02
- Cmax value higher than AUC nobody 2015-02-17 11:19
- Cmax value higher than AUC janmacek 2015-02-17 10:41
- Cmax value higher than AUC Dr_Dan 2015-02-17 18:53
- Cmax value higher than AUC nobody 2015-02-17 20:16
- Cmax value higher than AUC nobody 2015-02-17 09:38
- Cmax value higher than AUC ElMaestro 2015-02-16 14:01
- Cmax value higher than AUC msmnainar 2015-02-16 13:51
- Cmax value higher than AUC ElMaestro 2015-02-16 13:46