Bioequivalence and Bioavailability Forum • help test NCA BEAR

help test NCA BEAR [🇷 for BE/BA]

posted by Emrah Soner Özdeş – Turkey, 2015-01-15 15:37 (3382 d 18:23 ago) – Posting: # 14293
Views: 15,679

Dear yjlee168;

First of all I need to say that I am grateful for you guys for developing such a useful tool for BE/BA studies.

Currently I have the latest version of both R and the BEAR package. I am having the same issue mentioned in the first messaga of the thread.

It runs smooth until the 16th subject and stops in the 17th subjects, probably because of a BLOQ value in subject 17.

The workaround of manual selection of points worked fine with me. But as you guess it is not very practical and time consuming. I used to use WNL for NCA analysis, and have the feeling of the method of WNL for Lambdaz calculation (Rsq adjusted) is the most reliable one (I never tried the other methods).

So is there any other solution to this problem other than manuel selection ?

I found the solution before your reply.

I just replaced BLOQ values at the end with "NA" and it worked like a magic.

Got the hint from: http://pkpd.kmu.edu.tw/bear/

Best Regards

Emrah Soner Özdeş

Edit: Merged with a follow-up post. You can edit your original post for 24 hours. [Helmut]

Complete thread:

Difficulties with NCA BEAR PK_Lover 2014-11-21 00:28 [🇷 for BE/BA]
- Difficulties with NCA BEAR yjlee168 2014-11-21 07:34
  - Difficulties with NCA BEAR PK_Lover 2014-11-22 00:07
    - Difficulties with NCA BEAR yjlee168 2014-11-22 03:21
      - Difficulties with NCA BEAR PK_Lover 2014-11-22 09:47
        
        help test NCA BEAR yjlee168 2014-12-01 08:13
        
        help test NCA BEAREmrah Soner Özdeş 2015-01-15 14:37
        
        help test NCA BEAR Jam 2015-01-23 08:55
        
        CSV files with a comma at the end of each line? yjlee168 2015-01-25 04:35
      - Difficulties with NCA BEAR xtianbadillo 2016-09-15 22:44
        
        old bear and friends yjlee168 2016-09-16 09:42
        
        old bear and friends VStus 2016-09-26 13:30
        
        multiple-dosed study with bear yjlee168 2016-09-26 18:04
        
        multiple-dosed study with bear VStus 2016-10-11 09:01
        
        multiple-dosed study with bear yjlee168 2016-10-11 10:15
        
        multiple-dosed study with bear VStus 2016-10-11 10:37
        multiple-dosed study with bear VStus 2016-10-12 10:37
        
        multiple-dosed study with bear [solved] yjlee168 2016-10-12 18:42