Help calculate IVIVC [Dissolution / BCS / IVIVC]
Dear colleagues,
I am a beginning specialist, please help me with the following question. I cannot in any way calculate IVIVC with the aid of WinNonLin 5.2 with IVIVC wizard (I am earlier did not work with this program). I have pharmacokinetics and in vitro dissolution data for the preparation with immediate-release mechanism. Data are presented in attached file. Please describe the sequence of actions of calculation and briefly essence. How I understood for the present instance it is possible to calculate only the level C of correlation.
I do not know that to do and from what to begin.
Beforehand thankful all who will help!
P.S. Sorry of my English
Example of my data:
in vivo:
in vitro:
I am a beginning specialist, please help me with the following question. I cannot in any way calculate IVIVC with the aid of WinNonLin 5.2 with IVIVC wizard (I am earlier did not work with this program). I have pharmacokinetics and in vitro dissolution data for the preparation with immediate-release mechanism. Data are presented in attached file. Please describe the sequence of actions of calculation and briefly essence. How I understood for the present instance it is possible to calculate only the level C of correlation.
I do not know that to do and from what to begin.
Beforehand thankful all who will help!
P.S. Sorry of my English
Example of my data:
in vivo:
TabA (Ref) |TabB (Test)
Time(hr) |Concent(ng/ml) |Time |Concent(ng/ml)
0 |0 |0 |0
0.25 |124.076 | 0.25 |49.638
0.5 |296.299 | 0.5 |198.208
1 |269.707 | 1 |225.349
1.5 |238.699 | 1.5 |221.238
2 |205.115 | 2 |199.37
3 |151.659 | 3 |162.662
4 |107.232 | 4 |117.414
6 |68.252 | 6 |71.551
8 |50.73 | 8 |52.363
12 |31.607 | 12 |31.963
15 |26.059 | 15 |25.468
24 |10.854 | 24 |9.982
30 |3.278 | 30 |3.888
36 |0.588 | 36 |1.765
in vitro:
TabA (Ref) |TabB (Test)
Time(hr)|Fdiss_%|Time(hr)|Fdiss_%
pH 1.2
0 |0 |0 |0
0.08(3) |96.5 |0.08(3) |100.8
0.167 |101.8 |0.167 |102.1
0.25 |102.1 |0.25 |102.1
0.417 |102.2 |0.417 |102.2
0.58(3) |102.1 |0.58(3) |102.2
0.75 |102 |0.75 |102.2
pH 4.5
0 |0 |0 |0
0.08(3) |30.8 |0.08(3) |22.7
0.167 |55.3 |0.167 |46.9
0.25 |74.2 |0.25 |62.9
0.417 |93.9 |0.417 |80.3
0.58(3) |100 |0.58(3) |90
0.75 |101.4 |0.75 |95.6
pH 6.8
0 |0 |0 |0
0.08(3) |19.1 |0.08(3) |16.6
0.167 |36.5 |0.167 |31.3
0.25 |55 |0.25 |44.3
0.417 |73.3 |0.417 |59.2
0.58(3) |82.4 |0.58(3) |69.3
0.75 |86.6 |0.75 |75.6
Complete thread:
- Help calculate IVIVCPharmacist 2007-12-20 15:06
- Help calculate IVIVC Jaime_R 2007-12-20 20:41
- Help calculate IVIVC Pharmacist 2007-12-20 23:17
- Help calculate IVIVC Pharmacist 2008-01-15 01:00
- Help calculate IVIVC Pharmacist 2007-12-20 23:17
- Help calculate IVIVC Jaime_R 2007-12-20 20:41