Difficulties with NCA BEAR [🇷 for BE/BA]

posted by PK_Lover – Portugal, 2014-11-22 01:07 (3415 d 00:22 ago) – Posting: # 13911
Views: 16,184

Dear yjlee168,

thank you very much for your quick reply (I am honored!).

I am sorry for not replying earlier but I did not have access to the station where I have R installed until now.

Here is the setup (it is the default):

Methods Setting which_is
1 run demo? 0 no
2 study design? 0 2x2x2 crossover
3 single-/multiple-dose 0 single-dose
4 lambda_z estimate 0 adj. R sq. (ARS)
5 trapezoidal AUC 0 linear-up/log-down
6 BE criterion (LL) 80 lower limit
7 ODA? 0 no
8 dose? 100000 dose given
9 dosing interval 24 *multiple-dose only
10 Tlast 120 *multiple-dose only
11 pAUC? 0 all AUC
12 pAUC_start 121 the starting time of pAUC
13 pAUC_end 128 the end time of pAUC
14 IDP output? 0 no

The plot label of x-axis -> Time after Dosing (hr)
and the label of y-axis -> DrugX Plasma Conc. (ng/mL)


And I am using data from a simple Crossover design with 2 periods, single administration.

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