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RegisterBingo! [Two-Stage / GS Designs]
❝ • An option would be to use EMA’s approach of “leaving one out”; you would get only the pooled variance of the remaining pair.
Good day sirs!
In the above quote, is it statistically valid to establish ANOVA using drugs A and B only (as if done like a 2-way 2-seq crossover) in stage 1 (Potvin Method C) even though the study was done on a 3-way 6-seq crossover (Williams design) with drugs A, B and C? (asssuming the protocol specifically states that sequential BE shall be done on drugs A and B only; drug C shall be done for descriptive statistics determination only). Also, may I ask what specific EMA guideline mentioned the above approach so I could explore the topic further. I know a lot of discussion has already been poured on sequential BE, but I couldn't find a specific answer to my query. Many thanks in advance!
jerry
Complete thread:
- Two-stage three-treatment BE study? Oiinkie 2013-07-22 16:03 [Two-Stage / GS Designs]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Bingo! Helmut 2013-07-22 16:33
- Bingo! Oiinkie 2013-07-29 10:41
- Bingo! Helmut 2013-07-29 11:32
- Bingo! ElMaestro 2013-07-29 12:06
- Terms in Anova ElMaestro 2013-07-29 16:50
- annoying imbalance ElMaestro 2013-07-29 22:37
- Bingo! Helmut 2013-07-29 11:32
- Bingo!jatkins_5 2014-10-30 03:53
- Yes, however... ElMaestro 2014-10-30 08:59
- Yes, however... jatkins_5 2014-10-31 23:20
- Yes, however... ElMaestro 2014-10-30 08:59
- Bingo! Oiinkie 2013-07-29 10:41
- Bingo! Helmut 2013-07-22 16:33
Ing. Helmut Schütz