Bioequivalence and Bioavailability Forum • Group effects EMA

Group effects EMA [Two-Stage / GS Designs]

posted by ElMaestro – Denmark, 2014-10-01 13:31 (3487 d 22:01 ago) – Posting: # 13630
Views: 38,723

Hi Mittyri,

❝ More effects in model mean wider intervals.

❝ Please correct me if I'm wrong.

That's kind of incorrect.
The more effects you have in your model, the more variation is accounted for by the totality of terms; the residual will decrease as will be residual's degrees of freedom. Therefore the width of the CI tends to shrink.

It may happen that the inclusion of a term apparently does nothing. This is due to the design where some effect may contain the other; in such situation the residual variance, the residual df and the width of the CI remain unaffected. But you will never see the CI widened due to more factors.

—
Pass or fail!
ElMaestro

Complete thread:

Potvin C in the EU Helmut 2013-04-16 17:40 [Two-Stage / GS Designs]
- Potvin C in the EU ElMaestro 2013-04-17 02:31
  - Potvin C in the EU Helmut 2013-04-17 12:23
    - 2 Groups model FDA d_labes 2013-04-17 13:10
      - 2 Groups model FDA Helmut 2013-04-17 16:37
        
        Group effects obsolete? d_labes 2013-04-18 09:55
        
        Group effects FDA/EMA Helmut 2013-04-19 14:34
        
        Group effects FDA/EMA mittyri 2014-08-21 15:34
        
        Group effects FDA/EMA ElMaestro 2014-08-21 17:31
        
        Group effects EMA mittyri 2014-10-01 11:25
        
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        Fixed effects model with Group term VStus 2016-10-20 13:54
        
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        Group effects FDA/EMA Helmut 2017-06-03 14:57
        
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