Bioequivalence and Bioavailability Forum • Calculation of AUCt

Calculation of AUCt [NCA / SHAM]

posted by yckim – 2007-11-27 03:46 (6769 d 18:21 ago) – Posting: # 1334
Views: 36,523

Hi, its very nice to meet you.
The informations from this forum are very helpful. I very appreciate it.

I have a question.
how do you calculate the AUCt and do statistical analysis if there are concentrations below LOQ (at early or late sampling point)? As I know, the 't' time in AUCt should be the same time. Someone recommend to make it zero in the early time. And they also recommend to delete it in the late time to calculate the AUCinf. Is it meaningful to do statistical analysis of AUCt with different 't' value? Please let me know how to proceed the study in such a case.

Sorry for the poor english. ^^
Thank you.

Yu Chul Kim

Edit: Category changed. [Helmut]

Complete thread:

Calculation of AUCtyckim 2007-11-27 02:46 [NCA / SHAM]
- Calculation of AUCt, AUCall, AUCinf... Helmut 2007-11-27 22:02
  - Calculation of AUCt, AUCall, AUCinf... yckim 2007-11-28 02:44
    - Calculation of AUCt, AUCall, AUCinf... Helmut 2007-11-28 03:49
      - Calculation of AUCt, AUCall, AUCinf... jmlee 2008-10-10 08:29
        
        Calculation of AUCt, AUCall, AUCinf... Helmut 2008-10-10 17:48
        Calculation of AUCt, AUCall, AUCinf... mittyri 2014-03-19 19:15
        
        Errors happen d_labes 2014-03-20 08:26
        
        Errors happen fno 2014-03-20 11:03
  - Calculation of AUCt, AUCall, AUCinf... Ohlbe 2007-11-28 10:37
    - Calculation of AUCt, AUCall, AUCinf... Helmut 2007-11-28 12:28
      - References Helmut 2007-11-28 17:58