Bioequivalence and Bioavailability Forum

effectiveness of highly variable drugs [Off Topic]

posted by Ken Peh – Malaysia, 2013-12-17 04:45 (3775 d 17:46 ago) – Posting: # 12066
Views: 14,476

Dear Friends,

This is an off topic question.
We conducted BE studies on a highly variable drug, clopidogrel, a generic versus Plavix. The same subject who was dosed twice with the same product (irrespective of generic or comparator) showed drastic difference in AUC and Cmax. I was stunned when asked by a cardiologist what contributed to the high variability from the same product. Absorption, metabolism etc ?

Should highly variable drugs be used in clinical practice ??

Thank you for your kind sharing.

Regards,
Ken

Complete thread:

• effectiveness of highly variable drugsKen Peh 2013-12-17 03:45 
  • HVDs/HVDPs = safe drugs Helmut 2013-12-17 15:11
    • HVDs/HVDPs = safe drugs varun9461 2019-02-22 12:23
  • effectiveness of highly variable drugs Dr_Dan 2013-12-18 09:34
    • effectiveness of highly variable drugs Ohlbe 2013-12-18 10:07
      • effectiveness of highly variable drugs Ken Peh 2013-12-20 14:38
        • Period effect kumarnaidu 2014-01-28 07:54
          • Period effect Dr_Dan 2014-01-28 10:36
            • Period effect kumarnaidu 2014-01-28 11:51
              • Period effect Helmut 2014-01-28 13:48
                • Period effect kumarnaidu 2014-01-29 04:49