Enterohepatic recirculation [PK / PD]
Hi Helmut,
Thank you for exhaustive explanation!
The information from this forum is very helpful.
I've one more question following up upon this topic.
One of the subjects has actual data:
![[image]](img/uploaded/image68.jpg)
All points are BQL after last visible point.
So the question is: how to calculate the AUC part from tlast to infinity in this case with Winnonlin (what kind of points to collect for lambda z calculation & hl)?
Thank you for exhaustive explanation!
The information from this forum is very helpful.
I've one more question following up upon this topic.
One of the subjects has actual data:
![[image]](img/uploaded/image68.jpg)
All points are BQL after last visible point.
So the question is: how to calculate the AUC part from tlast to infinity in this case with Winnonlin (what kind of points to collect for lambda z calculation & hl)?
—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- Capecitabine: 2 slopes mittyri 2013-11-01 08:30 [PK / PD]
- Enterohepatic recirculation Helmut 2013-11-01 15:11
- Enterohepatic recirculationmittyri 2013-11-21 12:23
- WinNonlin: λz Helmut 2013-11-21 14:18
- WinNonlin: λz mittyri 2013-11-22 08:25
- WinNonlin: λz Helmut 2013-11-21 14:18
- Enterohepatic recirculationmittyri 2013-11-21 12:23
- Enterohepatic recirculation Helmut 2013-11-01 15:11