Bioequivalence and Bioavailability Forum • Using sampling “windows” for PK blood samples

Using sampling “windows” for PK blood samples [Design Issues]

posted by teuscher – US, 2013-11-15 16:16 (4605 d 09:28 ago) – Posting: # 11891
Views: 8,140

Ohlbe,

Thank you for your thoughtful response. I appreciate that there are differences in PK analysis to support specific projects such as bioequivalence studies. I have to say that I share in Helmut's frustration about using linear trapezoidal methods; however, I also understand that regulators want to standardize analyses. (Although they could standardize on linear up - log down, which would be more accurate than the current standard!)

Warm regards,
Nathan

Complete thread:

Using sampling “windows” for PK blood samples mittyri 2013-10-23 09:53 [Design Issues]
- Using sampling “windows” for PK blood samples jag009 2013-10-23 16:50
  - Using sampling “windows” for PK blood samples mittyri 2013-10-24 15:35
    - Using sampling “windows” for PK blood samples jag009 2013-10-25 05:12
      - Disagree with Nathan Helmut 2013-10-28 15:48
        
        Disagree with Nathan jag009 2013-10-28 20:36
      - Using sampling “windows” for PK blood samples teuscher 2013-11-15 03:55
        
        Using sampling “windows” for PK blood samples Ohlbe 2013-11-15 10:32
        
        Using sampling “windows” for PK blood samplesteuscher 2013-11-15 15:16
        
        Using sampling “windows” for PK blood samples Ohlbe 2013-11-15 15:55
        
        Lin/log trapezoidal Helmut 2013-11-17 14:55