estimated AUC72 [NCA / SHAM]
Dear John,
There are two queries from two different studies;
Situation 1: Situation somewhat similar to yours, where samples were collected up to 36 hrs post dose, but for some of the subjects AUCt could be calculated only up to 8 hrs, for some of the subjects it was up to 16 hrs and for some of the subjects up to 36 hrs.
Query 1: What approach we should implement while comparing such a variable AUCt? Is it a correct method to compare AUC8hrs to AUC36 hrs? Or Is there any other statistical method which we should adopt for such situation?
Situation 2: Samples were collected up to 36 hrs post dose and even achieved zero concentration quite before 36 hrs but still AUC% extrapolation was more than 20 % in many cases (e.g. profile is given in my earlier post)
Query 2: Since extrapolation is more than 20% how do we justify such situation?
I hope I am clear on this occasion.
Best Regards,
Ratnakar
There are two queries from two different studies;
Situation 1: Situation somewhat similar to yours, where samples were collected up to 36 hrs post dose, but for some of the subjects AUCt could be calculated only up to 8 hrs, for some of the subjects it was up to 16 hrs and for some of the subjects up to 36 hrs.
Query 1: What approach we should implement while comparing such a variable AUCt? Is it a correct method to compare AUC8hrs to AUC36 hrs? Or Is there any other statistical method which we should adopt for such situation?
Situation 2: Samples were collected up to 36 hrs post dose and even achieved zero concentration quite before 36 hrs but still AUC% extrapolation was more than 20 % in many cases (e.g. profile is given in my earlier post)
Query 2: Since extrapolation is more than 20% how do we justify such situation?
I hope I am clear on this occasion.
Best Regards,
Ratnakar
Complete thread:
- Actual time for PK analysis ratnakar1811 2013-10-07 08:07
- estimated AUC72 Helmut 2013-10-07 13:36
- estimated AUC72 ratnakar1811 2013-10-08 08:20
- estimated AUC72 sam 2013-10-08 13:15
- estimated AUC72 Helmut 2013-10-08 13:51
- estimated AUC72 ratnakar1811 2013-10-10 11:30
- estimated AUC72 jag009 2013-10-13 21:17
- estimated AUC72ratnakar1811 2013-10-15 06:23
- estimated AUC72 Dr_Dan 2013-10-15 12:24
- estimated AUC72 jag009 2013-10-15 21:53
- estimated AUC72 ratnakar1811 2013-10-17 09:34
- estimated AUC72ratnakar1811 2013-10-15 06:23
- estimated AUC72 jag009 2013-10-13 21:17
- estimated AUC72 ratnakar1811 2013-10-10 11:30
- estimated AUC72 ratnakar1811 2013-10-08 08:20
- estimated AUC72 Helmut 2013-10-07 13:36