t75% [NCA / SHAM]

posted by mittyri – Russia, 2013-08-28 11:51 (3866 d 03:32 ago) – Posting: # 11367
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Hi Helmut, Dan & K@K!

I have similar questions reading this guide.

There's no translation issue in chapter 6.2. In Russian we have the same.

❝ ❝ Would it be possible to be bioequivalent with regard to AUC and Cmax but failing with regard to t75%?


❝ Yes, it is, The Lászlós (who else?) have shown that. Will excavate the reference.


According russian guide t75% is calculated (chapter 6.1).
So the question is: what can we do with this data?
As you can see in chapter 7 (Statistical evaluation of bioequivalence) this parameter isn't used.
Would you explain this issue?

Kind regards,
mittyri

Kind regards,
Mittyri

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