t75% [NCA / SHAM]
Hi Dan,
Die Gnade der späten Geburt.
Useful for multiple peaks (see this example) and “flat profiles”. If you compare Cmax that might be apples-and-oranges-statistics. Actually Steinijans & Co. introduced this metric for prolonged release theophylline (see also the book by Hauschke, Steinijans, and Pigeot). I those dark ages there was even a saying:
Yes, it is, The Lászlós (who else?) have shown that. Will excavate the reference.
❝ ❝ the plateau time t75% is a rather old PK metric
❝ maybe I am too young, I never heard of it...
Die Gnade der späten Geburt.
❝ However, what would be the advantage of this parameter?
Useful for multiple peaks (see this example) and “flat profiles”. If you compare Cmax that might be apples-and-oranges-statistics. Actually Steinijans & Co. introduced this metric for prolonged release theophylline (see also the book by Hauschke, Steinijans, and Pigeot). I those dark ages there was even a saying:
“Volker Steinijans and his wife Theophylline”.
❝ Would it be possible to be bioequivalent with regard to AUC and Cmax but failing with regard to t75%?
Yes, it is, The Lászlós (who else?) have shown that. Will excavate the reference.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Russian Guidance – PK Data assay Karthikeyan 2013-08-27 13:54
- Plateau-time etc. Helmut 2013-08-27 14:44
- Russian Guidance – PK Data assay Dr_Dan 2013-08-27 15:39
- Russian Guidance – PK Data assay Helmut 2013-08-27 16:31
- t75% Dr_Dan 2013-08-27 16:56
- t75%Helmut 2013-08-27 17:37
- t75% mittyri 2013-08-28 09:51
- t75% (reporting only?) Helmut 2013-08-28 14:32
- t75% mittyri 2013-08-28 09:51
- t75%Helmut 2013-08-27 17:37
- t75% Dr_Dan 2013-08-27 16:56
- Partial AUC? Helmut 2013-08-28 17:42
- Partial AUC? Dr_Dan 2013-08-28 21:08
- Partial AUC? Karthikeyan 2013-08-29 14:04
- Partial AUC? Dr_Dan 2013-08-28 21:08
- Russian Guidance – PK Data assay Helmut 2013-08-27 16:31