Plateau-time etc. [NCA / SHAM]
Hi K@K,
What do you not understand? The PK metrics as such, or why they are mentioned in the guideline, or what?
t75% is the “Plateau time” – sometimes also called “POT-75” (Peak Occupancy Time 75%). The other metric is somewhat unusual. First calculate Cav = AUCτ/τ and then the time interval where C ≥Cav.
❝ For prolonged-released forms duration of time period is calculated when drug substance concentration is higher than mean steady-state value Css (T>Css), and T>75%Cmax.
What do you not understand? The PK metrics as such, or why they are mentioned in the guideline, or what?
t75% is the “Plateau time” – sometimes also called “POT-75” (Peak Occupancy Time 75%). The other metric is somewhat unusual. First calculate Cav = AUCτ/τ and then the time interval where C ≥Cav.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Russian Guidance – PK Data assay Karthikeyan 2013-08-27 13:54
- Plateau-time etc.Helmut 2013-08-27 14:44
- Russian Guidance – PK Data assay Dr_Dan 2013-08-27 15:39
- Russian Guidance – PK Data assay Helmut 2013-08-27 16:31
- t75% Dr_Dan 2013-08-27 16:56
- t75% Helmut 2013-08-27 17:37
- t75% mittyri 2013-08-28 09:51
- t75% (reporting only?) Helmut 2013-08-28 14:32
- t75% mittyri 2013-08-28 09:51
- t75% Helmut 2013-08-27 17:37
- t75% Dr_Dan 2013-08-27 16:56
- Partial AUC? Helmut 2013-08-28 17:42
- Partial AUC? Dr_Dan 2013-08-28 21:08
- Partial AUC? Karthikeyan 2013-08-29 14:04
- Partial AUC? Dr_Dan 2013-08-28 21:08
- Russian Guidance – PK Data assay Helmut 2013-08-27 16:31