Bioequivalence and Bioavailability Forum

Three-way crossover (WinNonlin) [Design Issues]

posted by Helmut  – Vienna, Austria, 2007-09-25 15:15 (6048 d 04:28 ago) – Posting: # 1132
Views: 30,525

Dear Nirali!

❝ Actully, I was under impression that WinNonlin is using the hypo:

❝ "MEAN(Test1)=MEAN(Test2)=MEAN(Ref)".

Again, we obtain only pairwise comparisons, not simultaneous ones.

❝ (A) suppose we have two REFERENCES and single TEST [R1, R2, T]for threeway comparison: if we select R1 as REFERENCE, WNL will calculate BE with hypo:

❝ (1) R1=T and (2) R1=R2.

Not quite, but very close.
If you run the BE wizard (R₁=reference), you will get
(1a) T vs. R₁, and
(1b) R₂ vs. R₁.
You have to run the BE wizard again (this time with R₂ as reference), getting
(2a) T vs. R₂, and
(2b) R₁ vs. R₂.
In order to get comparisons of T=R₁ and T=R₂, you have to run the wizard twice (results 1a and 2a), omitting 1b/2b. Of course PE and CL of 2b=1/1b.

❝ same way,

❝ (B) for two TEST and single REFERENCE [T1, T2, R]: if we select R as standard, hypo will be: (1) R=T1 and (2)R=T2

Yes this is correct; in this case only one run of the BE wizard is necessary, getting:
(1a) T₁ vs. R, and
(1b) T₂ vs. R.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Three-way crossover BABE Studies acfalcao 2007-09-16 22:34 
  • Three-way crossover example data set Helmut 2007-09-17 20:47
    • Three-way crossover example data set acfalcao 2007-09-17 23:02
      • Three-way crossover example data set Helmut 2007-09-18 12:47
        • Three-way crossover (WinNonlin) Nirali 2007-09-21 06:49
          • Three-way crossover (WinNonlin) Helmut 2007-09-21 13:04
            • Three-way crossover (WinNonlin) Nirali 2007-09-25 08:05
              • Three-way crossover (WinNonlin)Helmut 2007-09-25 13:15
        • Three-way crossover example data set Irene_I 2018-06-07 11:09
          • Three-way crossover example data set Helmut 2018-06-07 13:04
            • Three-way crossover example data set Irene_I 2018-06-08 11:09
            • Three-way crossover example data set Irene_I 2018-06-12 09:21
              • Leave-One-Out (IBD) Helmut 2018-06-12 12:42
                • Leave-One-Out (IBD) Irene_I 2018-06-13 05:02
                  • Impact of pooled variance (bias, CI) Helmut 2018-06-13 15:02
                • carry (over?) d_labes 2018-06-13 15:31
    • Pseudo-periods ElAlumno 2019-03-14 23:40
      • Pseudo-periods Helmut 2019-03-15 00:47
        • Two‐at‐a‐Time analysis in R ElAlumno 2019-03-22 21:59
          • fixed & mixed (dammit!) and a request to SASians Helmut 2019-03-23 01:03
            • Pooled vs IBD T-R in SAS from non-SASian mittyri 2019-03-23 23:13
              • Pooled vs IBD T-R in SAS from non-SASian Helmut 2019-03-23 23:36
            • mixed in R mittyri 2019-03-23 23:50
              • mixed in R (EMA B ≠ FDA) Helmut 2019-03-24 01:23
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