Bioequivalence and Bioavailability Forum

Dear HS,

Thanks for ur reply post.

do u have any idea about the intra CV of Lansoprazole?

from one published paper i got different CVintra for AUC and Cmax value of Lansoprazole. look this link
http://www.mhra.gov.uk/home/groups/l-unit1/documents/websiteresources/con2023110.pdf

and also from another paper i got a another CVintra for Lansoprazole.look this
http://www.mhra.gov.uk/home/groups/l-unit1/documents/websiteresources/con2023104.pdf

I want to find the Sample Size for a single dose 2 x 2 crossover design under fasting condition.

So which CVintra is best for finding the Sample Size?.

If we use the CVintra for Cmax value, the number of subjects required is almost double than that of CVintra of AUC value?

So please help me for finding the intra CV.

Thanks

mathews